Dapsone antibacterial agent, which is active concerning Mycobacterium leprae and tuberculosis. It has bacteriostatic action similar to antagonists of p-aminobenzoic acid.
Dapsone
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 100mg × 10 Pills | $4.45 | $44.53 + Bonus - 4 Pills | - | Add to cart |
| 100mg × 30 Pills | $3.17 | $95.22 + Bonus - 4 Pills | $38.40 | Add to cart |
| 100mg × 60 Pills | $2.85 | $171.24 + Bonus - 4 Pills | $96.00 | Add to cart |
| 100mg × 90 Pills | $2.75 | $247.28 + Bonus - 7 Pills Free Trackable Delivery | $153.00 | Add to cart |
| 100mg × 120 Pills | $2.69 | $323.30 + Bonus - 7 Pills Free Trackable Delivery | $211.20 | Add to cart |
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Dapsone product description
Dapsone is part of a group of substances called sulfones. The antibacterial result of Dapsone has the following mechanism, this substance, being a structural analog of para-aminobenzoic acid, interacts with dihydropyridine instead of para-aminobenzoic acid and competitively inhibits dihydropteroate synthetase. This prevents the synthesis of folic acid bacteria. Lack of folic acid, in turn, disrupts the formation of purines, pyrimidines and certain amino acids (methionine) of bacteria and, ultimately, leads to the cessation of bacterial growth. Dapsone has a bacteriostatic nature of the action, as it stops the growth and multiplication of bacteria, but does not cause their death.
Absorbed within 2-8 hours. It binds to plasma proteins by 70-90%, and the main metabolite of the drug - monoacetylldosone - by 99%. Metabolised in the liver to monoacetylldosone. Eliminated by the kidneys (70-85%) and through the gastrointestinal tract, 20% is excreted unchanged.
The drug is mainly used to treat leprosy and herpetiform dermatitis. During the treatment, it is necessary to perform a general blood test and monitor the liver transaminases, reticulocyte count, platelet count, methemoglobin concentration, urea nitrogen, creatinine. In addition, this medicine is designed for the treatment of tuberculosis, pneumonia caused by Pneumocystis carinii.
Dapsone safety information
The consumption of this medicine is oral. Dosing regimen is individual. As a part of combination therapy, this medical agent is used in a dosage of 50-100 mg/day or 1-2 mg/kg/day. If necessary, the maximum daily dosage is 300mg. The treatment procedure is long.
Among the contraindications, the manufacturer indicates hypersensitivity, incl. to sulfanilamides, a liver dysfunction, severe anemia, a deficiency of glucose-6-phosphate dehydrogenase or methemoglobin reductase (possibly the development of hemolytic anemia). The consumption of this medication during pregnancy and lactation is possible only for prevention therapy in patients with leprosy or herpetiform dermatitis.
Dapsone side effects
On the part of the blood: dose-dependent hemolysis with a growth in the level of hemoglobin and an growth in the amount of reticulocytes (in all patients), hemolytic anemia (pain in the back, legs, stomach area, loss of appetite, pallor of the skin, unusual fatigue or weakness, increase in body temperature), methemoglobinemia (cyanosis of the fingernails, lips or skin, shortness of breath, etc.), pathological changes in the blood (elevated body temperature, sore throat, unusual bleeding and hemorrhages, etc.), incl. agranulocytosis and hypoplastic anemia with fatal outcome, palpitation, cardialgia.
On the part of the skin: itching, dryness, redness or peeling of the skin, hair loss, toxic erythema, erythema multi-form, toxic epidermal necrolysis, nodular erythema, kore and scarlatina-like reactions.
On the part of the CNS and sensory organs: mental disorders, incl. mood changes, peripheral neuritis (sensation of numbness, tingling, burning, pain or weakness in the hands and feet), neurotoxicity (a headache, insomnia, nervousness).
On the part of allergic effects: skin rash, "sulphonic syndrome" (fever, malaise, exfoliative dermatitis, jaundice, lymphadenopathy, methemoglobinemia, anemia), usually develops after 6-8 weeks of therapy.
On the part of the digestive tract: liver damage (icterus sclera or skin), anorexia, nausea, vomiting.
Geodon - antipsychotic medicine (neuroleptic). It is taken at treatment of schizophrenia and similar mental disorders (treatment and prevention of aggravations), stopping of psychomotor excitement at patients with schizophrenia.
Cialis is a latest medicine for treatment of disturbances of erection at men. Cialis feature is its high-speed performance (30 minutes) and a long-term effect (up to 36 hours). In this regard you can choose the moment which is most suitable for sexual intercourse, having accepted a drug in advance. It is possible to take Cialis in the morning and to be ready even next day. Active ingredient - Tadalafil, the recommended dosage - 20 mg.
Brand Viagra - a drug from Pfizer, with a basic chemical called Sildenafil Citrate, is a first developed pharmaceutical to cure the difficulties with erection. It functions approximately within 4-5 hours, must be taken an hour prior to sex.
A tricyclic antidepressant with a relatively short latency period. It has almost no sedative effect. therapeutical indications include: depressive phases of a manic-depressive psychosis, all other forms of endogenous depression (reactive and neurotic). In combination with amitriptyline it is used for depressions that occurred during treatment with reserpine. In combination with neuroleptics, it is used in the treatment of depression that developed during treatment of schizophrenic psychoses.
Pamelor is a tricyclic antidepressant (TCA, tricyclic antidepressants) of the second generation. It is used in the treatment of some major depressive disorder and nocturnal enuresis (bedwetting) in children. In addition, the drug is sometimes used for the treatment of chronic diseases such as chronic fatigue syndrome, chronic pain and migraine, and the lability in certain neurological diseases.
Stromectol - a medical preparation that effectively cope with many kinds of parasites. It is used to treat lice, scabies, as well as onchocerciasis (river blindness) and other nematodes in humans and animals. It is applied externally and internally, depending on the disease.
Zocor is indicated to reduce mortality due to coronary artery disease. It is prescribed for the reduction of risk of serious vascular and coronary complications: non-fatal myocardial infarction, coronary death, stroke; revascularization operations. Designed to reduce the risk of the need for coronary blood flow restoration; rot reduce the risk of the need for surgical intervention to restore peripheral blood flow and other types of non-coronary revascularization; to reduce the risk of hospitalization in connection with attacks of angina pectoris; to decrease in the elevated level of total cholesterol, LDL cholesterol, triglycerides. apolipoprotein B; for increasing HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia.
Crestor - is a lipid-lowering drug that reduces the elevated cholesterol concentrations in the body.
Zantac - ranitidin - the drug is intended for the treatment of duodenal ulcers, benign gastric ulcer, postoperative ulcer, reflux esophagitis, Zollinger-Ellison syndrome, epigastric or chest pain. The administration of ranitidine is indicated in cases where a decrease in gastric secretion and a decrease in the production of hydrochloric acid is desirable, for the prevention of gastrointestinal bleeding, for the prevention of recurrence of bleeding in patients with bleeding ulcers of the stomach and duodenum, before general anesthesia in patients with a presumed risk of aspiration of acidic stomach contents (Mendelssohn syndrome), especially in women during childbirth delivery clashes.
An inhibitor of proton pump. The drug indications include: gastric ulcer and duodenal ulcer (in an acute phase), erosive gastritis, reflux-esophagit, Zolling-Erellison syndrome.
The drug has a thymoleptic and anxiolytic effect. Prescribed for the treatment of depressions of various origins, enuresis including the night one.
An antiaggregant, used for the prevention of thrombotic complications in patients with acute coronary syndrome (ACS), who are planned to undergo percutaneous coronary angioplasty and for prevention of stent thrombosis in acute coronary syndromes. The medicine is a receptor antagonist of P2Y12class to adenosine diphosphate (ADP), and consequently inhibits the activation and aggregation of platelets. Since platelets are involved in the development of atherosclerosis complications, the inhibition of platelet function may lead to a decrease in the frequency of cardiovascular complications.
Trileptal is used to treat simple and complex forms of partial epileptic seizures that have secondary generalization (possibly without it) beginning at the age of one month; generalized tonic-clonic forms of epileptic seizures in patients from two years of age. Reviews about Trileptal have a positive connotation, which allows to determine its effectiveness in use, thanks to patients who have experience of taking the drug.
An anti-migraine drug. Used for emergency treatment to eliminate migraine, with aura as well. A selective agonist of 5-hydroxytryptamine 1D receptors. The effect can be observed within 30 minutes after the intake.
Any dependence of the body on external influences is considered as human weakness and drug addiction. Perhaps one of the most common is nicotine addiction. Zyban helps to overcome it.
Xenical - a powerful, specific and reversible inhibitor of gastrointestinal lipases, which has a long-lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine portion of the gastric and pancreatic lipases. The inactivated enzyme at the same time loses the ability to break down food fats coming in the form of triglycerides, to sucking free fatty acids and monoglycerides. Since uncleaved triglycerides are not absorbed, the resulting decrease in the intake of calories into the body leads to a decrease in body weight. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.
Naprosyn is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 activity.
Clomid - anti-estrogen of nonsteroid structure which is taken for treatment of anovular infertility, dysfunctional metrorrhagia, amenorrhea, secondary amenorrheas, post-contraceptive amenorrheas, galactorrhoea (against the background of hypophysis tumor), syndrome of polycystic ovaries (sclerocystic disease of the ovary), Chiari-Frommel disease, androgenic insufficiency, oligospermatism, diagnosis of disturbances of gonadotropic function of hypophysis.
