Cefadroxil - cephalosporin antibiotic of the I generation for intake. It works as bactericidal, breaking synthesis of a cell wall of microorganisms. It has a broad spectrum of activity: it is active in relation as gram-positive (Staphylococcus spp. which don't produce and produce a penicillinase; Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis), and gram-negative microorganisms (Shigella spp., Salmonella spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., some strains of Proteus spp., especially Proteus mirabilis), Moraxella catarrhalis (Branhamella). Many strains of Enterococcus faecalis and Enterococcus faecium are steady against Cefadroxil.
Cefadroxil
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- Cefadroxil product description
Cefadroxil is a semi-synthetic antibiotic of the cephalosporin series. It has a bactericidal effect. The mechanism of action of Cefadroxil is connected with a violation of the synthesis of components of the membrane of bacterial cells.
Infections caused by microorganisms susceptible to Cefadroxil, namely: chronic otitis media and sinusitis; pharyngitis tonsillitis diseases of the lower respiratory tract (acute and chronic bronchitis, pneumonia), urinary tract viruses (complicated and uncomplicated); skin and soft tissue diseases, viruses of the bones and joints.
Cefadroxil safety information
Contraindications
Medicine is contraindicated in such cases:
- Hypersensitivity to cephalosporins. That is a possible cross-allergy potential, with strong sensitivity to penicillin.
- In speak about the therapy of nursing mothers, they mustn’t use breastfeeding. It can be started in 2 days after the end of medication.
Overdose
Features of the overdose of the remedy: nausea, hallucinations, hyperreflexia, extrapyramidal disorders, confusion, coma, renal dysfunction.
First actions after taking a toxic dose must be gastric lavage, hemodialysis if it is needed. In addition, the specialist has to make a monitoring, if necessary correction of water-electrolyte status, monitoring of kidney function.
Application features
The time between the intaking of Cefadroxil need to be increased in persons with existing renal insufficiency with prolonged use of Cefadroxil, the blood composition and functional status of the liver and kidneys have to be monitored. When allergic reactions and diarrhea occur, a course of remedy with Cefadroxil should be stopped. If you suspect pseudomembranous colitis caused by taking antibiotics, you should start therapy with vancomycin. Anti-peristaltic substances are contraindicated too.
A prolonged course of therapy can include hypovitaminosis K (hemorrhage), hypovitaminosis B (stomatitis, glossitis, neuritis, anorexia, etc.) and a false-positive direct Crumbs test: it should be borne in mind that positive results of the Coombs test are related to the use of Cefadroxil. This also applies to newborns whose mothers were treated with cephalosporins before childbirth.
Interaction with other medicinal products
The use of Cefadroxil in combination with aminoglycoside antibiotics, polymyxin B, whey or high doses of diuretics that affect reabsorption in the Henle loop is not desirable since such a combination contributes to the potentiation of the nephrotoxic effect. The risk of hemorrhagic complications enlarges with prolonged use of anticoagulants or platelet aggregation inhibitors, Cefadroxil may reduce the effectiveness of oral contraceptives.
Cefadroxil side effects
Often side conditions are observed from the gastrointestinal tract (nausea, vomiting, diarrhea, abdominal pain), occasionally allergic rashes on the skin, itching, rarely occur glossitis, dizziness, insomnia, anaphylactic shock. In some cases, there is an increase in opportunistic microorganisms (fungi), which can lead to vaginal mycoses, candidiasis stomatitis, etc.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
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Sumycin - An antibiotic based on tetracycline, a brand of such pharmaceutical companies as Bristol-Myers Squibb, Apothecon, Par Pharmaceutical.
Lisinopril is an antihypertensive, vasodilating, cardioprotective drug, an ACE inhibitor that is used to treat hypertension, heart failure, acute myocardial infarction, diabetic nephropathy.
Hydrea - antineoplastic medicine, antimetabolite, slows down DNA synthesis. It is used for treatment of acute and chronic myelogenous leukemia, osteomyelofibrosis, erythremia, essential thrombocythaemia, thrombocytosis associated with myeloproliferative syndrome, lymphogranulomatosis, melanoma, ovarian cancer, horionepitelioma of uterus, tumor of the head and the neck, tumor of brain, an acute lymphoblastic leukosis at children, a colon cancer, a prostate cancer, cancer of a lung, cancer of a neck of uterus (for increase in efficiency of radiation therapy).
Aldactone, which is spironolactone - is a competitive antagonist of aldosteron. In disteel kidney tubules increases removal of sodium and water, reduces - potassium. Lowers arterial pressure. It is prescribed at hyperaldosteronism, diagnostics of hyperaldosteronism, adenoma of adrenal glands, producing aldosterone; edema syndrome at chronic heart failure, cirrhosis, nephrotic syndrome, nephropathy of pregnant women; arterial hypertension, hypokalaemia, as additional medicine at malignant hypertension, hypokalaemia, prevention of hypokalaemia at patients with cardiac glycoside.
Pharmacological influence of Calan is explained by braking of a flow of calcium ions through the slowed-down calcic tubules of cellular covers of smooth muscle structure of vessels and a cardiac muscle. Calan is prescribed if it was diagnosed paroxysmal supraventricular tachycardia (except WPW syndrome), sinus tachycardia, premature atrial contraction, blinking and atrial flutter, stenocardia (inc. stress, postinfarction), arterial hypertension, hypertensive crisis, idiopathic hypertrophic subaortic stenosis, hypertrophic cardiomyopathy.
Keppra - antiepileptic drug, the mechanism of action is unclear, it does not alter normal synaptic transmission. Effective in both focal and epilepsy (epileptiform manifestations, photo paroxysmal reaction).
Colospa - myotropic spasmolytic with selective effect on unstriated muscles of digestive tract. Eliminates a spasm, without influencing a normal peristaltics of intestines. Unlike cholinolytic medicine, Colospa does not affect at muscarinic receptor and does not cause characteristic of antispasmodics with muscarinic receptor action of side effects (feeling of dryness in a mouth, vision disorders, an urination delay) that allows for patients to take it at prostatauxe or glaucoma. Taking of Colospa is not followed by development of reflex hypotonia of intestines.
Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.
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