Prochlorperazine is used to control severe nausea and vomiting in adults.
Prochlorperazine may also be used for purposes not listed in this medication guide.
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Drug uses
This medication is used to treat severe nausea and vomiting from certain causes (for example, after surgery or cancer treatment). Prochlorperazine belongs to a class of drugs known as phenothiazines. This medication is not recommended for use in children younger than 2 years or in children going through surgery.
Overdosage
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose can cause dry mouth, constipation, bloating or stomach cramps, extreme drowsiness or feeling restless and agitated, changes in heart rate, fever, and fainting.
Storage
Store at room temperature away from moisture and heat.
Safety information
Warnings
You should not use prochlorperazine if you have recently used alcohol, sedatives, tranquilizers, or opioid medication.
Prochlorperazine is not approved for use in older adults with dementia-related psychosis.
Do not give this medicine to a child younger than 2 years old or weighing less than 20 pounds.
Disclaimer
The information on this page is not intended to be a substitute for professional medical advice. Do not use this information to diagnose or treat your problem without consulting your doctor.
Side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
High doses or long-term use of prochlorperazine can cause a serious movement disorder that may not be reversible. The longer you use prochlorperazine, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult.
Call your doctor at once if you have:
- uncontrolled muscle movements in your arms, legs, or face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
- a light-headed feeling, like you might pass out;
- agitation;
- jaundice (yellowing of the skin or eyes);
- slow heart rate, weak pulse, fainting, slow breathing;
- fever, chills, sore throat, mouth sores;
- new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight; or
- severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Side effects such as dry mouth, constipation, confusion, and tremors may be more likely in older adults.
Common side effects may include:
- dizziness, drowsiness;
- feeling restless or jittery;
- blurred vision;
- constipation;
- breast swelling or discharge, a missed menstrual period;
- sleep problems (insomnia); or
- swelling in your hands or feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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A symptomatic medication against vomiting and nausea of various origins. Used at vomiting caused by radiation therapy or cytotoxic drugs intake, hypotony and atony of the stomach and intestines, biliary dyskinesia, reflux esophagitis, flatulence, aggravation of gastric ulcer and duodenal gut, when performing contrast studies of the gastrointestinal tract. It reduces the moving activity of the esophagus, increases the tone of the lower esophageal sphincter, accelerates gastric emptying, and accelerates the movement of food through the small intestine without causing diarrhea. Stimulates the secretion of prolactin.
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